Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach.

نویسندگان

  • Giuseppe Macchione
  • José L de Paz
  • Pedro M Nieto
چکیده

The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.

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عنوان ژورنال:
  • Carbohydrate research

دوره 394  شماره 

صفحات  -

تاریخ انتشار 2014