Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach.
نویسندگان
چکیده
The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.
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ورودعنوان ژورنال:
- Carbohydrate research
دوره 394 شماره
صفحات -
تاریخ انتشار 2014